Advocate (blue) for large dogs is a monthly topical spoton treatment to kill fleas, and control heartworm, hookworm, roundworm and whipworm infections, and control and manage lice. After application, Advocate spreads rapidly over your pet, killing 98100% of adult fleas within 12 hours of application. It also controls flea larvae in the pets environment and reduces the incidence of Flea Allergy Dermatitis. Advocate protects your pet against heartworm and intestinal worm infections , and controls lice for up to six weeks, and aids in the treatment of sarcoptic mange. Advocate for dogs is safe to use on puppies from the age of seven weeks. Use only as directed on the label and use correct size product only.